Current Grantees

Will non-invasive vagus nerve stimulation help improve upper limb function following stroke?

by Drs. Judith Schaechter & Vitaly Napadow

A randomized controlled trial of post-acute stroke patients is planned to provide preliminary evidence that non-invasive vagus nerve stimulation, combined with arm motor training, improves motor function of patients’ affected arm and hand.  Inves...
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Can median nerve stimulation restore consciousness following subarachnoid hemorrhage?

by Jan Claassen, M.D., Ph.D.

This study in patients who have lost consciousness following a subarachnoid hemorrhage will lay the foundation for undertaking larger-scale clinical trials to see whether stimulating patients’ median nerve helps them to regain consciousness. The ...
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Exploring a potential new therapy for fatal Canavan disease 

by David Pleasure, M.D.

Investigators will test in a mouse model a new approach to treating the fatal inherited condition in infants and children called ‘Canavan” disease. If promising, the research is anticipated to lead to human clinical testing of this first potential th...
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Determining how brain tumors suppress immune responses may accelerate immunotherapy advances

by Achal Singh Achrol, M.D.

This study aims to understand the molecular genetics of deadly brain glioblastomas (GBMs) and their interactions with the immune system, which may help improve the effectiveness of immunotherapies in this disease. Breakthroughs are critically need...
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Potent, selective sedative may reduce or prevent cognitive impairment after open heart surgery

by Stephen Choi, M.D., M. Sc.

This study will assess a treatment that may minimize cognitive impairment in patients following cardiac surgery. Up to 60 percent of cardiac surgery patients show persistent cognitive impairments for weeks or months following surgery. McKhann and...
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Technique may provide reliable brain biomarkers of improvements social skills in children with ASD

by Anjana Bhat, Ph.D.

This study will assess the reliability of a new brain imaging technique that captures the brain correlates of children with Autism Spectrum Disorder (ASD) as they imitate and synchronize activities with others. Children with ASD have problems maki...
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